Intermolecular C-H Amidation of Alkenes with Carbon Monoxide and Azides via Tandem Palladium Catalysis was written by Gu, Zheng-Yang;Wu, Yang;Jin, Feng;Bao, Xiaoguang;Xia, Ji-Bao. And the article was included in Synthesis in 2021.Name: 5-Chloro-2-methoxybenzoic acid This article mentions the following:
An atom- and step-economic intermol. multi-component palladium-catalyzed C-H amidation of alkenes with carbon monoxide and organic azides has been developed for the synthesis of alkenyl amides. The reaction proceeds efficiently without an ortho-directing group on the alkene substrates. Nontoxic dinitrogen is generated as the sole byproduct. Computational studies and control experiments have revealed that the reaction takes place via an unexpected mechanism by tandem palladium catalysis. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Name: 5-Chloro-2-methoxybenzoic acid).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: 5-Chloro-2-methoxybenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics