Synthesis and herbicidal activity of saflufenacil was written by Gao, Yong-chao;Chen, Ying-han;Zhou, Ding;Li, Lin. And the article was included in Nongyao in 2012.Formula: C8H6ClFO2 This article mentions the following:
Saflufenacil is a new kind of herbicide with excellent herbicidal activity. The aim is to study its synthesis, anal. method and evaluate herbicidal activity. Me 5-amino-2-chloro-4-fluorobenzoate (5) was produced from 2-chloro-4-fluorobenzoic acid by esterification, nitration and reduction, then reacted with triphosgene to give Me 2-chloro-4-fluoro-5-isocyanatobenzoate (6), 6 was cyclized with Et 3-amino-4,4,4-trifluorobut-2-enoate, then methylated, followed by hydrolysis to obtain 2-chloro-5-(2, 6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-l (6H)-yl)-4-fluorobenzoic acid (10), which was reacted with N-methyl-N-iso-Pr sulfamide to give target compound Overall yield was 6.26%. The chem. structures were confirmed by 1H NMR, IR and MS. Purity was 99.8% by HPLC anal. The herbicidal activities of the target compound and purchased saflufenacil were compared. And the same results were obtained. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Formula: C8H6ClFO2).
Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C8H6ClFO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics