Synthesis of 1,2,3,4-tetrafluorobenzene by potassium fluoride fluorination was written by Finger, G. C.;Shiley, R. H.;Dickerson, D. R.. And the article was included in Journal of Fluorine Chemistry in 1974.HPLC of Formula: 2613-34-5 This article mentions the following:
1,2,3,4-C6H2F4 (I) was prepared in ∼26% yield by reaction of 2,3,6-F3C6H2Cl with KF-CsF in Me2SO2 at ∼265° for 1.5-2 hr. With KF alone the yield of I was 16.4%. The yield of I by similar reaction with 2,3,4-F3C6H2Cl did not exceed 2.5% even when CsF was used alone. The fluorination of 2,3,1,4-Cl2F2C6H2 via this halogen exchange reaction gave 22.6% I, but under similar conditions 3,4,1,2- and 2,4,1,3-Cl2F2C6H2 gave I in 1.8 and 1.3% yield, resp. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5HPLC of Formula: 2613-34-5).
3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 2613-34-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics