Examining the structure-activity relationship of benzopyran-based inhibitors of the hypoxia inducible factor-1 pathway was written by Ferguson, Jalisa;De Los Santos, Zeus;Devi, Narra;Van Meir, Erwin;Zingales, Sarah;Wang, Binghe. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:
Many forms of solid tumor have a characteristic feature known as hypoxia, which describes a low or nonexistent presence of oxygen in the cellular microenvironment. This decrease in oxygen causes activation of the hypoxia inducible factor (HIF) pathway, which activates the transcription of many genes that cause cell proliferation, metastasis, increased glycolysis and angiogenesis. Increased HIF expression has been linked with poor patient prognosis, increased malignancy, and therapeutic resistance. Previous work in the lab has identified I and II as inhibitors of the HIF pathway, specifically as disrupters of the p300-HIF-1α complex formation. A library of sulfonamide analogs has been designed and synthesized with the intent of examining the SAR of this series of compounds and improving potency and physicochem. properties as compared with lead compounds I and II. At the end, the authors have achieved a thorough understanding of the structural features critical for future optimization work. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics