Multistep Solvent-Free 3 m2 Footprint Pilot Miniplant for the Synthesis of Annual Half-Ton Rufinamide Precursor was written by Escriba-Gelonch, Marc;de Leon Izeppi, Gerardo Antonio;Kirschneck, Dirk;Hessel, Volker. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.SDS of cas: 697-73-4 This article mentions the following:
The development of a pilot-scale synthesis of the rufinamide precursor in flow chem. is reported. Complex steps such as Taylor-flow, segmented flow, and high-temperature processing at high pressure (high-p,T) are successfully combined, overcoming the mixing and heat transfer issues of the scale-up. The cascaded multistep process operates essentially solvent-free in just 3 m2 giving a productivity of 47 g/h (>400 kg/yr), which increases by a factor of 7 the lab-scale productivity previously reported as a scale-up proof-of-concept. This publication also includes an economic study of the feasible implementation of this technol. for a possible manufacturer, as well as an outline on business development strategies of how to implement such a disruptive technol. The development of a pilot-scale synthesis of the rufinamide precursor in flow chem. is reported. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 697-73-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics