Chemical constitution and the dissociation constants of monocarboxylic acids. XV. Steric effects in substituted nitrobenzoic acids was written by Dippy, J. F. J.;Hughes, S. R. C.;Laxton, J. W.. And the article was included in Journal of the Chemical Society in 1956.Recommanded Product: 2-Chloro-6-nitrobenzoic acid This article mentions the following:
The dissociation constants were determined conductimetrically in H2O at 25° for 2,3-(O2N)2C6H3CO2H (I), 2,4-(O2N)2C6H3CO2H (II), 2,5-(O2N)2C6H3CO2H (III), 2,6-(O2N)2C6H3CO2H (IV), 3,4-(O2N)2C6H3CO2H (V), 3,5-(O2N)2C6H3CO2H (VI), 2,3-Cl(O2N)C6H3CO2H (VII), 2,4-Cl(O2N)C6H3CO2H (VIII), 2,5-Cl(O2N)C6H3CO2H (IX), 2,6-Cl(O2N)C6H3CO2H (X), 2,6-Br(O2N)C6H3CO2H (XI), 2,4,6-(O2N)3C6H2CO2H (XII), 4,3,5-Me(O2N)2C6H2CO2H (XIII), 2-O2NC6H4OH (XIV), 2,6-(O2N)2C6H3OH (XV), and 2,4,6-(O2N)3C6H2OH (XVI). The results shed light on the operation of steric effects in the BzOH system. V was prepared from 3,4-(O2N)2C6H3Me by oxidation with KMnO4 in 50% H2SO4. Refluxing 2,4-(O2N)2C6H3Me with equal volumes of fuming HNO3 and AcOH gave II. I and XII were prepared from PhEt and 2,4,6-(O2N)3C6H2Me, resp. All acids were recrystallized repeatedly from conductivity H2O to constant m.p. after drying several weeks in desiccators, and equivalents were confirmed by alkalimetry. Measurements were made with an improved bridge network and equipment already described (loc. cit.). Solutions were prepared individually by weight at each concentration The thermodynamic dissociation constants were calculated along the usual lines. A solvent correction was applied in the derivation of K for XIV. Fuoss’s extrapolation method (cf. C.A. 29, 28248), in which measurements of the equivalent conductivity of the aqueous acid are used, were employed for the determination of Λ0. Dissociation constants × 103 found were: I, 14.1; II, 37.6; III, 23.9; IV, 72.5; V, 1.52; VI, 1.50; VII, 9.51; VIII, 10.9; IX, 6.80; X, 45.5; XI, 42.4; XII, 222; and XIII, 1.07. For the phenols the dissociation constants were: XIV, 5.9 × 10-8; XV, 1.97 × 10-4; and XVI, 1.96 × 10-1. The values of Λ0 exhibit none of the regularities usual in related monocarboxylic acids. This is perhaps connected with the fact that in this series anomalies are introduced by large steric factors which are likely to influence variously and anomalously the solvation characteristics of the different anions. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Recommanded Product: 2-Chloro-6-nitrobenzoic acid).
2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 2-Chloro-6-nitrobenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics