Efficient and Scalable Synthesis of Ethyl 2,6-Dichloro-5-Fluoronicotinoyl Acetate Using the Blaise Reaction as a Key Step was written by Choi, Bo Seung;Chang, Jay Hyok;Choi, Hyeong-wook;Kim, Young Keun;Lee, Ki Kon;Lee, Kyu Woong;Lee, Jae Hoon;Heo, Taeho;Nam, Do Hyun;Shin, Hyunik. And the article was included in Organic Process Research & Development in 2005.Category: chlorides-buliding-blocks This article mentions the following:
An efficient synthesis of 2,6-dichloro-5-fluoronicotinoyl acetate (I) has been accomplished in a single step using the Blaise reaction of Et bromoacetate with 3-cyano-2,6-dichloro-5-fluoropyridine. Use of methanesulfonic acid as an in situ activator of zinc removed the induction period of the Blaise reaction to render it safe and viable for a large-scale operation. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Category: chlorides-buliding-blocks).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics