Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) Receptor was written by Cho, Nobuo;Harada, Masataka;Imaeda, Toshihiro;Imada, Takashi;Matsumoto, Hirokazu;Hayase, Yoji;Sasaki, Satoshi;Furuya, Shuichi;Suzuki, Nobuhiro;Okubo, Shoichi;Ogi, Kazuhiro;Endo, Satoshi;Onda, Haruo;Fujino, Masahiko. And the article was included in Journal of Medicinal Chemistry in 1998.COA of Formula: C7H5ClF2 This article mentions the following:
The authors describe the design, synthesis, and biol. properties of iso-Pr 3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-(4-isobutyrylaminophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate hydrochloride (I, T-98475), a hightly potent and orally active nonpeptide antagonist of the human LHRH receptor. The results of in vitro and in vivo studies demonstrate that T-98475 is the first potent and orally effective nonpeptide antagonist of the human LHRH receptor, and should provide a new class of useful therapeutic agents for the treatment of sex hormone-dependent pathologies. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C7H5ClF2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics