Synthesis and evaluation of halogenated 12N-sulfonyl matrinic butanes as potential anti-coxsackievirus agents was written by Cheng, Xin-Yue;Li, Yu-Huan;Tang, Sheng;Zhang, Xin;Wang, Yan-Xiang;Wang, Sheng-Gang;Jiang, Jian-Dong;Li, Ying-Hong;Song, Dan-Qing. And the article was included in European Journal of Medicinal Chemistry in 2017.Safety of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:
Twenty-eight new 12N-benzenesulfonyl matrinic butane and halogenated 12N-sulfonyl matrinic butane/ethane derivatives were designed, synthesized and evaluated for their anti-coxsackievirus activities against CVB3. SAR anal. indicated the introduction of a fluoro atom on the 1′-position might be helpful for keeping potency. Among them, compound I exhibited potential activities against all CVBs with IC50 ranging from 0.69 to 5.14 μM, suggesting a broad-spectrum anti-coxsackievirus B feature. In addition, it also displayed an excellent PK and a good safety profile, indicating a highly druggable nature. Thus, we consider compound I to be a promising drug candidate in the treatment of not only viral myocarditis caused by CVB3 but also various diseases infected with coxsackieviruses B. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Safety of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics