Synthesis and evaluation of homo-bivalent GnRHR ligands was written by Bonger, Kimberly M.;van den Berg, Richard J. B. H. N.;Heitman, Laura H.;IJzerman, Ad P.;Oosterom, Julia;Timmers, Cornelis M.;Overkleeft, Herman S.;van der Marel, Gijsbert A.. And the article was included in Bioorganic & Medicinal Chemistry in 2007.SDS of cas: 697-73-4 This article mentions the following:
G protein coupled receptors (GPCRs) are important drug targets in pharmaceutical research. Traditionally, most research efforts have been devoted towards the design of small mol. agonists and antagonists. An interesting, yet poorly investigated class of GPCR modulators comprise the bivalent ligands, in which two receptor pharmacophores are incorporated. Here, we set out to develop a general strategy for the synthesis of bivalent compounds based on the imidazopyrimidinone I that are projected to bind to the human gonadotropin-releasing hormone receptor (GnRHR). Our results on the dimerization of a known GnRHR antagonist, with as key step the Huisgen 1,3-cycloaddition, and their ability to bind to and antagonize GnRH-induced GnRHR stimulation, are presented here. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 697-73-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics