Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90 was written by Biamonte, Marco A.;Shi, Jiandong;Hong, Kevin;Hurst, David C.;Zhang, Lin;Fan, Junhua;Busch, David J.;Karjian, Patricia L.;Maldonado, Angelica A.;Sensintaffar, John L.;Yang, Yong-Ching;Kamal, Adeela;Lough, Rachel E.;Lundgren, Karen;Burrows, Francis J.;Timony, Gregg A.;Boehm, Marcus F.;Kasibhatla, Srinivas R.. And the article was included in Journal of Medicinal Chemistry in 2006.Quality Control of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:
Orally active Hsp90 inhibitors are of interest as potential chemotherapeutic agents. Recently, fully synthetic 8-benzyladenines and 8-sulfanyladenines such as 4 were disclosed as Hsp90 inhibitors, but these compounds are not water soluble and consequently have unacceptably low oral bioavailabilities. We now report that water-solubility can be achieved by inserting an amino functionality in the N(9) side chain. This results in compounds that are potent, soluble in aqueous media, and orally bioavailable. In an HER-2 degradation assay, the highest potency was achieved with the neopentylamine 42 (HER-2 IC50 = 90 nM). In a murine tumor xenograft model (using the gastric cancer cell line N87), the H3PO4 salts of the amines 38, 39, and 42 induced tumor growth inhibition when administered orally at 200 mg/kg/day. The amines 38, 39, and 42 are the first Hsp90 inhibitors shown to inhibit tumor growth upon oral dosage. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Quality Control of 2-(3-Methoxyphenyl)acetyl chloride).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of 2-(3-Methoxyphenyl)acetyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics