Synthesis, Antimycobacterial Activity and 3-D QSAR Studies of Some New Derivatives of p-Hydroxybenzohydrazide was written by Bhole, Ritesh. P.;Bhusari, Kishore P.. And the article was included in QSAR & Combinatorial Science in 2009.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:
Various N’-[3-(4-substituted alkyl/aryl thiaiazolidin-2-ylidene]-4-hydroxy benzohydrazide (4.a-i) and N’-[-(3,4-disubstituted)-1,3-thiazolidin-2-ylidene)]-4-hydroxybenzohydrazide from (5.a-i) to (10.a-i) were synthesized using appropriate synthetic route. The entire test compounds (4.a-i) and compounds from (5.a-i) to (10.a-i) were assayed in vitro against H37Rv strain of M. tuberculosis. The min. inhibitory concentration (MIC) was determined for test compounds and for reference standards The test compounds showed significant antimycobacterial activity against the microbial strains used, when tested in vitro. In general, p-hydroxybenzohydrazide ring and substituted thiazoline ring are essential for antimicrobial activity. Among the compounds tested, compounds 5.i (I), 6.f, 7.d, 8.g and 9.f were found to be most potent. The test compounds were found to be nontoxic up to a dose level of 1000 μg/mL. All compounds were then subjected for 3D-QSAR studies. 3D-QSAR study based on the principal of alignment of pharmacophoric features by Schrodinger PHASE module. The 3D-QSAR study allowed us to confirm the preferential binding mode of p-hydroxybenzohydrazide inside the active site. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics