Inhibition of the Human Proteasome by Imidazoline Scaffolds was written by Azevedo, Lauren M.;Lansdell, Theresa A.;Ludwig, Jacob R.;Mosey, Robert A.;Woloch, Daljinder K.;Cogan, Dillon P.;Patten, Gregory P.;Kuszpit, Michael R.;Fisk, Jason S.;Tepe, Jetze J.. And the article was included in Journal of Medicinal Chemistry in 2013.Electric Literature of C8H9ClO4S This article mentions the following:
The proteasome has emerged as the primary target for the treatment of multiple myeloma. Unfortunately, nearly all patients develop resistance to competitive-type proteasome inhibitors such as bortezomib. Herein, the optimization of noncompetitive proteasome inhibitors to yield derivatives that exhibit nanomolar potency (compound I, IC50 130 nM) toward proteasome inhibition and overcome bortezomib resistance is described. These studies illustrate the feasibility of the development of noncompetitive proteasome inhibitors as additives and/or alternatives to competitive proteasome inhibitors. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C8H9ClO4S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics