Derivatives of 1-(2-(Piperidin-1-yl)ethyl)-1H-benzo[d]imidazole: Synthesis, Characterization, Determining of Electronic Properties and Cytotoxicity Studies was written by Akkoc, Senem. And the article was included in ChemistrySelect in 2019.Quality Control of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
A series of 1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazole derivatives I•X (R = CH2CH2OH, 2-MeC6H4CH2, 1-naphthalenylmethyl, etc.; X = Br, Cl) were synthesized and fully characterized. The geometry optimization was carried out using the d. functional theory (DFT) method and the electronic properties of compounds I (R = CH2CH2OH; X = Br) and I (R = 2-MeC6H4CH2; X = Cl) hydrochloride salts were calculated Furthermore, all the compounds were evaluated for their potential anticancer activity towards different human cell lines. While I (R = 1-naphthalenylmethyl; X = Cl) demonstrated important cytotoxic activity against human colorectal adenocarcinoma epithelial colon cell line (DLD-1) with an IC50 value of 15.56 +/- 4.01 μM, compound I (R = 4-MeC6H4CH2; X = Cl) hydrochloride showed the most anticancer activity towards human liver epithelial hepatocellular carcinoma cell line (HepG2) with IC50 value of 15.16 μM. Moreover, microscopic examination of cells was done using Leica inverted microscopy and Olympus confocal microscope. Confocal images of DLD-1 and human normal epithelial virus transformed cell line (Beas-2B), which were treated with 20 μM of compounds, indicated that compounds I (R = 4-MeC6H4CH2; X = Cl) hydrochloride and I (R = 1-naphthalenylmethyl; X = Cl) had more cytotoxic activity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Quality Control of 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics