CON4EI: Development of testing strategies for hazard identification and labelling for serious eye damage and eye irritation of chemicals was written by Adriaens, E.;Verstraelen, S.;Alepee, N.;Kandarova, H.;Drzewiecka, A.;Gruszka, K.;Guest, R.;Willoughby, J. A. Sr.;Van Rompay, A. R.. And the article was included in Toxicology In Vitro in 2018.Electric Literature of C10H8Cl2FNO3 This article mentions the following:
Assessment of acute eye irritation potential is part of the international regulatory requirements for safety testing of chems. In the last decades, many efforts have been made in the search for alternative methods to replace the regulatory in vivo Draize rabbit eye test (OECD TG 405). Success in terms of complete replacement of the regulatory in vivo Draize rabbit eye test has not yet been achieved. The main objective of the CEFIC-LRI-AIMT6-VITO CON4EI (CONsortium for in vitro Eye Irritation testing strategy) project was to develop tiered testing strategies for serious eye damage and eye irritation assessment that can lead to complete replacement of OECD TG 405. A set of 80 reference chems. (e.g., balanced by important driver of classification and phys. state), was tested with seven test methods. Based on the results of this project, three different strategies were suggested. The authors have provided a standalone (EpiOcular ET-50), a two-tiered and three-tiered strategy, that can be used to distinguish between Cat 1 and Cat 2 chems. and chems. that do not require classification (No Cat). The two-tiered and three-tiered strategies use an RhCE test method (EpiOcular EIT or SkinEthic EIT) at the bottom (identification No Cat) in combination with the BCOP LLBO (two-tiered strategy) or BCOP OP-KIT and SMI (three-tiered strategy) at the top (identification Cat 1). For the authors’ proposed strategies, 71.1% – 82.9% Cat 1, 64.2% – 68.5% Cat 2 and â?0% No Cat chems. were correctly identified. Also, similar results were obtained for the Top-Down and Bottom-Up approach. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Electric Literature of C10H8Cl2FNO3).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C10H8Cl2FNO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics