Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors was written by Abdelazem, Ahmed Z.;Al-Sanea, Mohammad M.;Park, Byung Sun;Park, Hye Mi;Yoo, Kyung Ho;Sim, Taebo;Park, Jong Bae;Lee, Seung-Hoon;Lee, So Ha. And the article was included in European Journal of Medicinal Chemistry in 2015.SDS of cas: 85953-29-3 This article mentions the following:
With the aim of discovering potent and selective kinase inhibitors targeting ROS1 kinase, we designed, synthesized and screened a series of new pyrazol-4-ylpyrimidine derivatives based on our previously discovered lead compound KIST301072. Compounds I (R’ = H, Me) showed good to excellent activities against ROS1 kinase, and seven out of tested compounds were more potent than KIST301072. Compound I (R = CH2CH2CH2CH2OH, R’ = H) was the most potent with IC50 of 24 nM. Moreover, compound I (R = CH2CH2CH2CH2OH, R’ = H) showed ROS1 inhibitory selectivity of about 170-fold, relative to that of ALK sharing about 49% amino acid sequence homol. with ROS1 kinase in the kinase domain. In silico modeling of 7c at ROS1 active site revealed some essential features for ROS1 inhibitory activity. Based on this study and the previous studies, we could build a hypothetical model predicting the required essential features for ROS1 inhibitory activity. The model validity was tested through a second set of compounds In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3SDS of cas: 85953-29-3).
Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 85953-29-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics