Design, synthesis, single-crystal and preliminary antitumor activity of novel arenesulfonylimidazolidin-2-ones was written by Abdel-Aziz, Alaa A.-M.;El-Azab, Adel S.;El-Subbagh, Hussein I.;Al-Obaid, Abdulrahman M.;Alanazi, Amer M.;Al-Omar, Mohamed A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Reference of 63624-28-2 This article mentions the following:
Mono(arylsulfonyl) and bis(arylsulfonyl) dimethoxyimidazolidinones I [R = PhSO2, 2-naphthylsulfonyl, 4-MeC6H4SO2, 4-MeOC6H4SO2, 4-ClC6H4SO2, 2,4-(MeO)2C6H3SO2, 2,4-Cl2C6H4SO2, 2,4,6-Me3C6H2SO2, 2,4,6-(Me2CH)3C6H2SO2; R1 = H, R] were prepared as cyclic analogs of the antitumor agent sulofenur and tested for their antitumor activity in a variety of human cancer cell lines. Bromination of 1,3-diacetyl-2-imidazolone followed by treatment with DIPEA and methanol gave I (R = H; R1 = MeCO); sulfonylation followed by cleavage of the remaining acetyl group yielded I [R = PhSO2, 2-naphthylsulfonyl, 4-MeC6H4SO2, 4-MeOC6H4SO2, 4-ClC6H4SO2, 2,4-(MeO)2C6H3SO2, 2,4-Cl2C6H4SO2, 2,4,6-Me3C6H2SO2, 2,4,6-(Me2CH)3C6H2SO2; R1 = H], while cleavage of the remaining acetyl group followed by disulfonylation gave I [R = R1 = PhSO2, 2-naphthylsulfonyl, 4-MeC6H4SO2, 4-MeOC6H4SO2, 4-ClC6H4SO2, 2,4-(MeO)2C6H3SO2, 2,4-Cl2C6H4SO2, 2,4,6-Me3C6H2SO2, 2,4,6-(Me2CH)3C6H2SO2]. Bis(arylsulfonyl) dimethoxyimidazolidinones were more active against cancer cells than the corresponding mono(arylsulfonyl) dimethoxyimidazolidinones, with bis(arylsulfonyl) dimethoxyimidazolidinones showing particular activity against lung and kidney cancer cell lines. I (R = R1 = 4-ClC6H4) showed remarkable broad-spectrum antitumor activity. The structure of I [R = 2,4-(MeO)2C6H3SO2; R1 = H] was determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 63624-28-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics