Syntheses of halogenated methoxybenzophenone derivatives and their cytoprotective activities against H2O2-induced injury in HUVECs was written by Zhang, Yuanlin;Feng, Xiue;Gao, Jie;Li, Qingshan. And the article was included in Huaxue Tongbao in 2014.Related Products of 3438-16-2 This article mentions the following:
Twelve kinds of halogenated methoxybenzophenone derivatives were designed and synthesized using methoxy and halogen substituted benzoic acids as starting materials through acylation of carboxylic acid, Friedel-Crafts acylation and halogenation reaction in turn, and their structures were confirmed by ESI-MS, 1H NMR and 13C NMR. Their protective activities against H2O2-induced injury in human umbilical vein endothelial cell (HUVECs) were investigated to explore the structure-activity relationships. The results showed that the compounds I and II exhibited high cytoprotective activities at 12.5 μmol/L, the protective rates were over 50%. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Related Products of 3438-16-2).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 3438-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics