Cu-Catalysed intramolecular radical enantioconvergent tertiary β-C(sp3)-H amination of racemic ketones was written by Yang, Chang-Jiang;Zhang, Chi;Gu, Qiang-Shuai;Fang, Jia-Heng;Su, Xiao-Long;Ye, Liu;Sun, Yan;Tian, Yu;Li, Zhong-Liang;Liu, Xin-Yuan. And the article was included in Nature Catalysis in 2020.Electric Literature of C7H4ClF3O2S This article mentions the following:
Herein, the combination of decoupled hydrogen atom abstraction with asym. copper catalysis for enantioconvergent tertiary β-C(sp3)-H amination of racemic ketones was described. This method, when allied with follow-up transformations, provided facile access to a range of enantioenriched compounds I [R = t-Bu, Ph, 3-thienyl, etc.; R1 = Me, CH2CO2Me, allyl, etc.; R2 = Ph, 2-thienyl, 3-thienyl, 3-MeC6H4; Ar = Ph, 4-tolyl, 2-naphthyl, etc.] featuring quaternary stereocenters. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C7H4ClF3O2S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics