Base-Mediated Decarboxylative [3+2] Annulation of Ethynyl Benzoxazinanones and Benzimidamides: Synthesis of Imidazole Derivatives was written by Wang, Lan;Jiang, Feng;Gao, Xing;Wang, Wei;Wu, Yongjun;Guo, Hongchao;Zheng, Bing. And the article was included in Advanced Synthesis & Catalysis in 2021.Application of 18637-02-0 This article mentions the following:
A base-mediated decarboxylative [3+2] annulation of trimethylsilylethynyl benzoxazinanones I (R = H, 6-Me, 5-Cl, 8 -F, etc.; R1 = H, trimethylsilyl) and benzimidamides hydrochloride R3C(=NH)NH2•HCl (R3 = H, 2-methylphenyl, 3-chlorophenyl, 6-chloropyridin-3-yl, etc.) was achieved under mild reaction conditions to give various imidazole derivatives II (R4 = H, 4-Me, 3-Cl, 2-F, etc.) in high yields. Notably, it demonstrated a new reaction mode of alkynyl benzoxazinanones. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Application of 18637-02-0).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 18637-02-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics