Synthesis and antidiabetic activity of N’-[3-(alkyl/aryl substituted)-4-oxo-1,3-thiazolidinylidene]-2-(2-pyrazinyloxy)acetohydrazide was written by Verma, Prabhakar;Kamboj, Vipan. And the article was included in Acta Pharmaceutica Sciencia in 2010.Electric Literature of C7H3Cl2NS This article mentions the following:
2-(2-Pyrazinyloxy)acetic acid 2-(3-alkyl-4-oxo-2-thiazolidinylidene)hydrazide and 2-(2-pyrazinyloxy)acetic acid 2-(3-aryl-4-oxo-2-thiazolidinylidene)hydrazide derivatives were designed for a study of their biol. activity, the synthesis of the target compounds was achieved using 2(1H)-pyrazinone, chloroacetic acid Et ester and isothiocyanates as starting materials and the products thus obtained were confirmed by m.p., TLC, UV, IR, NMR. The title compounds were evaluated in a dexamethasone-induced hyperglycemia model and hyperinsulinemia model and it was discovered that these compounds displayed activity as antidiabetic agents with reduced toxicity in comparison with rosiglitazone. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Electric Literature of C7H3Cl2NS).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C7H3Cl2NS
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics