A formal method for the de-N,N-dialkylation of Sommelet-Hauser rearrangement products was written by Tayama, Eiji;Sato, Ryota;Takedachi, Keisuke;Iwamoto, Hajime;Hasegawa, Eietsu. And the article was included in Tetrahedron in 2012.Recommanded Product: Methyl 2-chloro-2-phenylacetate This article mentions the following:
Selective amine de-alkylation enables the conversion of Sommelet-Hauser rearrangement products into 2-aryl-2-bromoacetic acid derivatives These compounds are valuable synthetic intermediates in the synthesis of α-aryl-α-amino or α-aryl-β-amino acid derivatives The method presented herein is a formal de-N,N-dialkylation of Sommelet-Hauser rearrangement products. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Recommanded Product: Methyl 2-chloro-2-phenylacetate).
Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: Methyl 2-chloro-2-phenylacetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics