Pd/Cu-Catalyzed tandem head-to-tail dimerization/cycloisomerization of terminal ynamides for the synthesis of 5-vinyloxazolones was written by Tang, Luning;Huang, Hai;Xi, Yang;He, Guangke;Zhu, Hongjun. And the article was included in Organic & Biomolecular Chemistry in 2017.HPLC of Formula: 18437-66-6 This article mentions the following:
An attractive and novel methodol. involving Pd/Cu-catalyzed tandem head-to-tail dimerization/cycloisomerization of terminal ynamides HCCN(Boc)R (R = Ph, 2-MeC6H4, 4-FC6H4, 4-MeOC6H4CH2, etc.) for the synthesis of 3,5-disubstituted oxazolones I was developed. Under Pd(PPh3)2Cl2/CuI cooperative catalyzed reaction conditions, the reaction provided efficient access to 5-vinyloxazolones with exceptional functional group tolerance and good chemoselectivity. The control experiments demonstrated that Pd(PPh3)2Cl2 serves a key role in the dimerization of terminal ynamides and shows low catalytic activity in the intramol. cyclization. Moreover, the hetero-Diels-Alder reaction of product 5-vinyloxazolones was also described, which provided polycyclic oxazolones in good yield. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6HPLC of Formula: 18437-66-6).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 18437-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics