Benzo[f]naphthyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens was written by Tabart, Michel;Picaut, Guy;Lavergne, Marc;Wentzler, Sylvie;Malleron, Jean-Luc;Dutka-Malen, Sylvie;Berthaud, Nadine. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Computed Properties of C6H4ClF2N This article mentions the following:
The synthesis and antibacterial activity of benzo[f][1,7]naphthyridones, e.g., I, are reported. These compounds are potent antibacterial agents with a Gram-pos. spectrum of activity. They are active against multi-resistant cocci, especially Staphylococcus aureus strains. Their physico-chem. and biol. properties make them particularly suitable for topical antibacterial use. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5Computed Properties of C6H4ClF2N).
3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C6H4ClF2N
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics