Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH was written by Singh, Vinayak;Pacitto, Angela;Donini, Stefano;Ferraris, Davide M.;Boros, Sandor;Illyes, Eszter;Szokol, Balint;Rizzi, Menico;Blundell, Tom L.;Ascher, David B.;Pato, Janos;Mizrahi, Valerie. And the article was included in European Journal of Medicinal Chemistry in 2019.Category: chlorides-buliding-blocks This article mentions the following:
In prior work, (cyclohexyl(4-(isoquinolin-5-ylsulfonyl)piperazin-1-yl)methanone) was identified and showed that its anti-tubercular activity is attributable to inhibition of inosine-5′-monophosphate dehydrogenase (IMPDH) in Mycobacterium tuberculosis. In the present study, the structure-activity relationship around (cyclohexyl(4-(isoquinolin-5-ylsulfonyl)piperazin-1-yl)methanone) was explored by synthesizing and evaluating the inhibitory activity of analogs against M. tuberculosis IMPDH in biochem. and whole-cell assays. X-ray crystallog. was performed to elucidate the mode of binding of selected analogs to IMPDH. The importance of the cyclohexyl, piperazine and isoquinoline rings was estabilished for activity and reported the identification of an analog with IMPDH-selective activity against a mutant of M. tuberculosis that is highly resistant to (cyclohexyl(4-(isoquinolin-5-ylsulfonyl)piperazin-1-yl)methanone). It was showed that the nitrogen in urea analogs is required for anti-tubercular activity and identify benzylurea derivatives as promising inhibitors that warrant further investigation. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Category: chlorides-buliding-blocks).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics