Romine, Jeffrey L. et al. published their research in Journal of Medicinal Chemistry in 2007 | CAS: 3438-16-2

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application of 3438-16-2

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: Opener of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels, Identification, Solubility, and SAR was written by Romine, Jeffrey L.;Martin, Scott W.;Meanwell, Nicholas A.;Gribkoff, Valentin K.;Boissard, Christopher G.;Dworetzky, Steven I.;Natale, Joanne;Moon, Sandra;Ortiz, Astrid;Yeleswaram, Swamy;Pajor, Lorraine;Gao, Qi;Starrett, John E. Jr.. And the article was included in Journal of Medicinal Chemistry in 2007.Application of 3438-16-2 This article mentions the following:

BMS-191011 (I), an opener of the cloned large-conductance, Ca2+-activated potassium (maxi-K) channel, demonstrated efficacy in in vivo stroke models, which led to its nomination as a candidate for clin. evaluation. Its maxi-K channel opening properties were consistent with its structural topol., being derived by combining elements from other known maxi-K openers. However, I suffered from poor aqueous solubility, which complicated elucidation of SAR during in vitro evaluation. The activity of I in in vivo stroke models and studies directed toward improving its solubility are reported herein. Enhanced solubility was achieved by appending heterocycles to the I scaffold, and a notable observation was made that inclusion of a simple amino group (anilines II and III) yielded excellent in vitro maxi-K ion channel opening activity and enhanced brain-to-plasma partitioning compared to the appended heterocycles. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Application of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics