Arylacetonitriles: application in syntheses of 2,1-benzisoxazoles was written by Orlov, V. Y.;Kotov, A. D.;Ganzha, V. V.;Mironov, G. S.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2003.Synthetic Route of C8H5ClFN This article mentions the following:
A series of 2,1-benzisoxazoles, e.g. I (R = Ph, 3-ClC6H4, 2-MeC6H4, 4-MeOC6H4, etc.), was synthesized by cyclocondensation of the corresponding nitrobenzene derivative, e.g. 4-chloronitrobenzene, with arylacetonitriles RCH2CN, and the substituent effect on the product yield was studied. It is shown that when the aromatic ring of the R fragment contains electron-donating or halogen substituents, the yield of the products depends on the position of these substituents in the aromatic ring. The introduction of electron-accepting substituents partially or completely inhibits the reaction. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9Synthetic Route of C8H5ClFN).
2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C8H5ClFN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics