Synthesis of Isoxazolines and Isoxazoles Inspired by Fipronil was written by Miller, Daniel K.;Bailey, Christopher A.;Sammelson, Robert E.. And the article was included in Synthesis in 2015.Safety of 4-Bromo-3,5-dichlorobenzotrifluoride This article mentions the following:
The synthesis of novel isoxazole and isoxazoline heterocycles that have similar structural features to the com. used phenylpyrazole, fipronil is described. Synthesis of the appropriately substituted styrenes and phenylacetylenes is followed by 1,3-dipolar cycloaddition reaction with several aliphatic nitrile oxides, which are prepared in situ from aldoximes with bleach. Relative reaction rates were determined for these specialized alkene and alkyne dipolarophiles. In the experiment, the researchers used many compounds, for example, 4-Bromo-3,5-dichlorobenzotrifluoride (cas: 118754-53-3Safety of 4-Bromo-3,5-dichlorobenzotrifluoride).
4-Bromo-3,5-dichlorobenzotrifluoride (cas: 118754-53-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of 4-Bromo-3,5-dichlorobenzotrifluoride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics