Palladium-catalyzed reductive desulfonative aminocarbonylation of benzylsulfonyl chlorides with nitroarenes towards arylacetamides was written by Liu, Yongzhu;Bao, Zhi-Peng;Qi, Xinxin;Wu, Xiao-Feng. And the article was included in Organic Chemistry Frontiers in 2022.Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
A new palladium-catalyzed reductive desulfonative aminocarbonylation reaction with benzylsulfonyl chlorides RCH2S(O)2Cl (R = Ph, 3,4-dimethylphenyl, 2,4-dichlorophenyl, etc.) as C(sp3) electrophiles has been developed. Using nitroarenes R1NO2 (R1 = Ph, quinolin-8-yl, 2H-1,3-benzodioxol-5-yl, etc.) as readily accessible and stable nitrogen surrogates, a wide range of arylacetamides RCH2C(O)NHR1 were easily prepared in high yields with very good functional group compatibility. Mo(CO)6 plays a dual role as both a CO source and reductant. Moreover, a late-stage modification of natural products was also achieved via this aminocarbonylation strategy. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics