The potential transformation mechanisms of the marker components of Schizonepetae Spica and its charred product was written by Liu, Xindan;Zhang, Ying;Wu, Menghua;Ma, Zhiguo;Cao, Hui. And the article was included in Molecules in 2020.Category: chlorides-buliding-blocks This article mentions the following:
Schizonepetae Spica (SS) is commonly used for treating colds, fevers, bloody stool and metrorrhagia in China. To treat colds and fevers, traditional Chinese medicine doctors often use raw SS, while to treat bloody stool and metrorrhagia, they usually use Schizonepetae Spica Carbonisata (SSC; raw SS processed by stir-frying until carbonization). However, there have been limited investigations designed to uncover the mechanism of stir-fry processing. In the present study, a method combining gas chromatog.-mass spectrometry (GC-MS) and high-performance liquid chromatog. (HPLC) was developed for the comprehensive anal. of the chem. profiles of SS and SSC samples. Principal component anal. of the GC-MS data demonstrated that there were 16 significant differences in volatile compounds between the SS and SSC samples. The simultaneous quantification of six nonvolatile compounds was also established based on HPLC, and remarkable differences were found between the two products. These changes were probably responsible for the various pharmacol. effects of SS and SSC as well as the observed hepatotoxicity. Finally, the mechanisms could be rationalized by deducing possible reactions involved in the transformation of these marker components. This work reports a new strategy to reveal the chem. transformation of SS during stir-fry processing. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Category: chlorides-buliding-blocks).
1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics