Base-Mediated Three-Component Tandem Reactions for the Synthesis of Multisubstituted Pyrimidines was written by Liu, Dongqing;Guo, Wei;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Journal of Organic Chemistry in 2017.Quality Control of 2-Chloro-benzamidine hydrochloride This article mentions the following:
A base-mediated three-component tandem reaction for the synthesis of multi-substituted pyrimidines from amidines, aryl alkynes, and aldehydes in a one-pot manner has been developed. Advantages of this transformation include being transition-metal-free, high efficiency, available starting materials, and being environmentally friendly. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Quality Control of 2-Chloro-benzamidine hydrochloride).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 2-Chloro-benzamidine hydrochloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics