Site-Selective Carbene-Induced C-H Functionalization Catalyzed by Dirhodium Tetrakis(triarylcyclopropanecarboxylate) Complexes was written by Liao, Kuangbiao;Liu, Wenbin;Niemeyer, Zachary L.;Ren, Zhi;Bacsa, John;Musaev, Djamaladdin G.;Sigman, Mathew S.;Davies, Huw M. L.. And the article was included in ACS Catalysis in 2018.Reference of 7476-66-6 This article mentions the following:
Three types of dirhodium tetrakis(triarylcyclopropanecarboxylate) complexes were generated and shown to adopt disparate high-symmetry structures. These catalysts were evaluated in the intermol. C-H functionalization of an array of terminally substituted n-alkanes and displayed various site-selectivity as a function of catalyst and substrate structure, which could be correlated through quant. relationships. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Reference of 7476-66-6).
Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 7476-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics