Synthesis and antibacterial activity of thiazolo-, oxazolo-, and imidazolo[3,2-a][1,8]naphthyridinecarboxylic acids was written by Kondo, Hirosato;Taguchi, Masahiro;Inoue, Yoshimasa;Sakamoto, Fumio;Tsukamoto, Goro. And the article was included in Journal of Medicinal Chemistry in 1990.Application of 96568-04-6 This article mentions the following:
Title compounds I (R = H, X = S; R = Me, X = O; R = H, X = NMe) were synthesized from dichlorofluoropyridyloxopropionate II and evaluated for antibacterial activity in vitro and for inhibitory activity against DNA gyrase of Escherichia coli K-12 C600. I (R = H, X = S) exhibited antibacterial activity comparable to that of ofloxacin and enoxacin against Gram-pos. and Gram-neg. bacteria and displayed antibacterial activity superior to that of I (R = Me, X = O; R = H, X = NMe), whereas, the antibacterial activity of I (R = Me, X = O) was greater than that of I (R = H, X = NMe). The DNA gyrase inhibitory activities of I paralleled their in vitro antibacterial activity. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Application of 96568-04-6).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 96568-04-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics