Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives was written by Khan, Khalid Mohammed;Qurban, Saira;Salar, Uzma;Taha, Muhammad;Hussain, Shafqat;Perveen, Shahnaz;Hameed, Abdul;Ismail, Nor Hadiani;Riaz, Muhammad;Wadood, Abdul. And the article was included in Bioorganic Chemistry in 2016.COA of Formula: C7H3Cl2NS This article mentions the following:
Current study based on the synthesis of new thiazole derivatives via “one pot” multicomponent reaction, evaluation of their in vitro α-glucosidase inhibitory activities, and in silico studies. All synthetic compounds were fully characterized by 1H NMR, 13C NMR and EIMS. CHN anal. was also performed. These newly synthesized compounds showed activities in the range of IC50 = 9.06±0.10-82.50±1.70 μM as compared to standard acarbose (IC50 = 38.25±0.12 μM). It is worth mentioning that most of the compounds exhibited potent inhibitory potential. Mol. docking study was performed in order to understand the mol. interactions between the mol. and enzyme. Newly identified α-glucosidase inhibitors except few were found to be completely nontoxic. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1COA of Formula: C7H3Cl2NS).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C7H3Cl2NS
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics