Quality assurance and harmonization for targeted biomonitoring measurements of environmental organic chemicals across the Children′s Health Exposure Analysis Resource laboratory network was written by Kannan, Kurunthachalam;Stathis, Alexa;Mazzella, Matthew J.;Andra, Syam S.;Barr, Dana Boyd;Hecht, Stephen S.;Merrill, Lori S.;Galusha, Aubrey L.;Parsons, Patrick J.. And the article was included in International Journal of Hygiene and Environmental Health in 2021.HPLC of Formula: 101-20-2 This article mentions the following:
A consortium of laboratories established under the Children′s Health Exposure Anal. Resource (CHEAR) used a multifaceted quality assurance program to promote measurement harmonization for trace organics analyses of human biospecimens that included: (1) participation in external quality assurance (EQA)/proficiency testing (PT) programs; (2) analyses of a urine-based CHEAR common quality control (QC) pool with each anal. batch across all participating laboratories; (3) method validation against NIST Standard Reference Materials (SRMs); and (4) analyses of blinded duplicates and other project-specific QC samples. The capability of five CHEAR laboratories in organic chem. anal. increased across the 4-yr period, and performance in the external PT program improved over time – recent challenges reporting >90% analytes with satisfactory performance. The CHEAR QC pools were analyzed for several classes of organic chems. including phthalate metabolites and environmental phenols by the participating laboratories with every batch of project samples, which provided a rich source of measurement data for the assessment of intra- and inter-laboratory variance. Within-laboratory and overall variabilities in measurements across laboratories were calculated for target chems. in urine QC pools; the coefficient of variation (CV) was generally below 25% across batches, studies and laboratories and indicated acceptable anal. imprecision. The suite of organic chems. analyzed in the CHEAR QC pool was broader than those reported for com. available reference materials. The accuracy of each of the laboratories methods was verified through the anal. of several NIST SRMs and was, for example, 97 ± 5.2% for environmental phenols and 95 ± 11% for phthalates. Anal. of blinded duplicate samples showed excellent agreement and reliability of measurements. The intra-class correlation coefficients (ICC) for phthalate metabolites analyzed in various batches across three CHEAR laboratories showed excellent reliability (typically >0.90). Overall, the multifaceted quality assurance protocols followed among the CHEAR laboratories ensured reliable and reproducible data quality for several classes of organic chems. Increased participation in external PT programs through inclusion of addnl. target analytes will further enhance the confidence in data quality. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2HPLC of Formula: 101-20-2).
1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 101-20-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics