Monomethylthio analogs of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane was written by Jacob, Peyton III;Anderson, George III;Meshul, Charles K.;Shulgin, Alexander T.;Castagnoli, Neal Jr.. And the article was included in Journal of Medicinal Chemistry in 1977.Product Details of 63624-28-2 This article mentions the following:
Title analogs 1-(4,5-dimethoxy-2-methylthiophenyl)- (I) [69587-04-8], 1-(2,4-dimethoxy-5-methylthiophenyl)- (II) [69587-03-7], and 1-(2,5-dimethoxy-4-methylthiophenyl)-2-aminopropane-HCl (III) [61638-08-2] were prepared from the appropriate dimethoxybenzenes by chlorosulfonation or sulfation followed by reduction to the thiophenol derivative, S-methylation, Vilsmeier formylation, condensation with nitroethane [79-24-3], and reduction Only III had significant activity in the rabbit hyperthermia assay. Time-concentration studies of the analogs as well as differences in enantiomeric ratios in rat brains following i.p. administration of each analog racemate were carried out. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Product Details of 63624-28-2).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 63624-28-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics