Hutchings, B. L. et al. published their research in Journal of the American Chemical Society in 1952 | CAS: 3438-16-2

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Degradation of aureomycin was written by Hutchings, B. L.;Waller, C. W.;Gordon, S.;Broschard, R. W.;Wolf, C. F.;Goldman, A. A.;Williams, J. H.. And the article was included in Journal of the American Chemical Society in 1952.Category: chlorides-buliding-blocks This article mentions the following:

Preceding abstract Alkali fusion of aureomycin (I) yielded 5,2-Cl(HO)C6H3CO2H, Me2NH, and NH3. Methylation, followed by permanganate oxidation, gave the following derivatives: 6-chloro-3-methoxyphthalic acid, m. 186-8° (anhydride, m. 187-8°); a monobasic acid (II), m. 199-200° (decomposition), [α]25D 25° (MeOH), formed a mono-Me ester, m. 96-100° and on decarboxylation gave 1 mole CO2 and 4-chloro-7-methoxy-3-methylphthalide (III), m. 112-13°. II is 4-chloro-7-methoxy-3-methylphthalide-3-carboxylic acid. Oxidation of III with alk. permanganate yielded 6-chloro-3-methoxyphthalonic acid (IV), m. 224-7° (decomposition), or 6-chloro-3-methoxyphthalic acid, depending on whether the MnO2 was filtered off before or after acidification. Oxidation in neutral solution yielded 3-hydroxy-3-methyl-4-chloro-7-methoxyphthalide (V), m. 198-203°; methylation of V gave a normal ester, m. 69-70°, and a pseudo ester, m. 188-90°. The oxidation residues gave a dibasic acid (VI), m. 211-12°, [α]25D -20.2° (EtOH). VI heated with Ac2O gave an anhydride m. 209-10°. VI is putative 4-chloro-7-methoxy-3-methylphthalide-3-succinic acid. A 2nd dibasic acid (VII), m. 203-4°; di-Me ester, m. 108-9.5°; anhydride, m. 200-1°. VII demethylated with HBr yielded a phenolic acid, m. 172.5-75°; acid oxidation with permanganate yielded tricarballylic acid. VII is putative 3-(4-chloro-7-methoxy-3-methylphthalidyl)glutaric acid. Alk. fusion of the phthalide derivatives (except III) gave 5,2-Cl(MeO)C6H3CO2H. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Category: chlorides-buliding-blocks).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics