Sustainable and highly controlled aryl couplings revealed by systematic assessment of photoactivatable linkers was written by Haensch, Veit G.;Neuwirth, Toni;Bergner, Alexander;Bruhnke, Jakob;Kloss, Florian;Hertweck, Christian. And the article was included in Chemical Science in 2022.COA of Formula: C19H15Cl This article mentions the following:
A metal-free, photochem. alternative (“photosplicing”) for the selective preparation of a wide range of pharmaceutically important biphenyls was reported. Whereas the traceless sulfonamide linker enabled and controls the aryl coupling, unwanted toxic byproducts were released. Therefore, it designed over 25 different temporary linkers and tested them for their suitability for the photosplicing reaction in a flow reactor. A surprisingly high number of functional groups enabled light-induced aryl fusion and identified a number of linkers for environmentally friendly procedures. A thiol-ene (click) – photosplicing sequence enabled a convenient route to biaryls such as liquid crystals. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5COA of Formula: C19H15Cl).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C19H15Cl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics