Base mediated direct C-H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants was written by Guo, Wei. And the article was included in Chinese Chemical Letters in 2016.Synthetic Route of C7H8Cl2N2 This article mentions the following:
A direct metal-free C-H amination reaction of cinnamaldehydes and amidines to realize the synthesis of polysubstituted pyrimidines was developed in the presence of base. This greener synthetic methodol. provides a straightforward approach to the synthesis of a variety of pyrimidine derivatives under mild reaction conditions using oxygen as the sole oxidant. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Synthetic Route of C7H8Cl2N2).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C7H8Cl2N2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics