Formylation of some sulfides of the furan series was written by Gol’dfarb, Ya. L.;Yakubov, A. P.;Belen’kii, L. I.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1965.Product Details of 3438-16-2 This article mentions the following:
Furfuryl chloride added at 5-10° to Me3CSH in aqueous alc. KOH and kept 18 hrs. gave 87% α-furfuryl tert-Bu sulfide, b8 76-7°, n20D 1.5012, d20 0.9944; similarly prepared was 93% α-furfuryl phenyl sulfide, b0.06 75-6°, 1.5960, 1.1414. Furfuryl mercaptan and PhCH2Cl gave 89% benzyl α-furfuryl sulfide, b0.9 111-12° n20D 1.5825, d20 1.1402. The products were treated in Me2NCHO with POCl3 at 0-20° 2.75 hrs. and after quenching in ice gave the following 5-alkyl(aryl)thiomethyl-2-furancarboxaldehydes (the R of the RS group in the compounds, b.p., n20D, and d20 shown): Et, b0.2 90-1°, 1.0575 (sic), 1.1538; iso-Pr, b1.2 104-6°, 1.6558, 1.1119; Bu, b2 130-1°, 1.0550 (sic), 1.0937; Me3C, b2 117° (m. 26-7.5°), -, -; Ph, b0.1 132-40° (m. 24.5-5°), -, -; PhCH2, b0.1 145-6° (m. 35-6° ), -, -. The latter oxidized with Ag2O to the corresponding carboxylic acid, m. 122-3°. The iso-Pr analog also gave the acid, m 95°. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Product Details of 3438-16-2).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 3438-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics