Funcke, A. B. H. et al. published their research in Arzneimittel-Forschung in 1956 | CAS: 7476-66-6

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of Methyl 2-chloro-2-phenylacetate

Studies on spasmolytics. III. Influence of structural changes in nitrogen-free esters with spasmolytic activity was written by Funcke, A. B. H.;Rekker, R. F.;Ernsting, M. J. E.;Nauta, W. Th.. And the article was included in Arzneimittel-Forschung in 1956.Application In Synthesis of Methyl 2-chloro-2-phenylacetate This article mentions the following:

The following esters of α-chlorophenylacetic acid were prepared from the acyl chloride and resp. alc. (b.°/mm., nD20 and yield in % are given): Me 123-6/11, 1.4963, 60; Et 132-3/15, 1.5037, 65; Pr 140-2/19, 1.5024, 55; iso-Pr 125-30/8, 1.5010, 55; Bu 143-5/8, 1.4960, 65; iso-Bu 135-40/8, 1.4958, 30; Am 143-5/11 1.5028, 79; 2-Me-1-Bu 144-6/11, 1.5028, 81; 3-Me-1-Bu 145-7/11, 1.5029, 55; 2,2-dimethylpropyl 141-3/11, 1.4983, 68; 2-pentyl 144-5/11, 1.5023, 78; 2-Me-2-Bu 148-50/12, m. 70-2°, 83; 3-Me-2-Bu 146-8/12, 1.5018, 90; 3-pentyl 144-5/11, 1.5035, 69; 3,3,5-trimethyl-1-cyclohexyl 140/0.04, 1.5135, 81. The lower esters of the series have a higher spasmolytic activity than the corresponding mandelates; as the number of C atoms in the ester group increases, however, this relation is inversed. The following esters of phenylglyoxylic acid have little or no spasmolytic activity: 2-Me-1-Bu 118/0.02, 1.5058, 53; 1-heptyl 128/0.03, 1.4980, 61; 2,6-dimethyl-4-heptyl 125/0.05, 1.4900, 55; 3,3,5-trimethyl-1-cyclohexyl 145/0.05, m. 43-4°, 77. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Application In Synthesis of Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics