Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method was written by Fang, Y.;Tranmer, G. K.. And the article was included in Organic & Biomolecular Chemistry in 2016.Product Details of 36157-41-2 This article mentions the following:
Synthesis of thieno[3,2-c]quinolin-4(5H)-ones I [R1 = H, Me, Cl, OMe; R2 = H, Cl; R3 = H, Cl, CF3, etc.] and benzo[h]-1,6-naphthyridin-5(6H)-ones II [R1 = H, Cl] via continuous flow photocyclization of phenylthiophene-carboxamides and phenylnicotinamides resp. was described. Overall, the continuous flow method provided access to complex heterocycles in two steps from com. available starting materials in good yields and with greater atom efficiency than traditional batch reactions. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Product Details of 36157-41-2).
2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 36157-41-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics