Copper-Oxone Promoted Oxidative C-H Functionalization: Synthesis of 2-Aminobenzothiazoles and Evaluation of Their Antimicrobial Activities was written by Dogan, Senguel Dilem;Guenduez, Miyase Gozde;Ugur, Suemeyye Buran;Dogan, Hilal;Ozkul, Ceren;Cetinkaya, Yasin. And the article was included in ChemistrySelect in 2021.Reference of 6590-96-1 This article mentions the following:
Therefore, a convenient, rapid and efficient methodol. for the ring closure reaction of thioureas to form 2-aminobenzothiazole derivatives This study optimized the reaction conditions by trying various catalysts and oxidants. Copper iodide/oxone catalysis provided the best conditions for the preparation of benzothiazoles. The regioselectivity observed in the ring closure reaction of the naphthyl thiourea derivative was investigated and the obtained exptl. results were supported by theor. calculations In-vitro antimicrobial effects of the compounds were tested against various bacterial and fungal strains. Finally, mol. docking studies were carried out to rationalize the achieved biol. results and suggest mol. modifications to design new benzothiazole derivatives In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Reference of 6590-96-1).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 6590-96-1
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics