Synthesis of quinolin-2-one alkaloid derivatives and their inhibitory activities against HIV-1 reverse transcriptase was written by Cheng, Pi;Gu, Qiong;Liu, Wei;Zou, Jian-Feng;Ou, Yang-Yong;Luo, Zhong-Yong;Zeng, Jian-Guo. And the article was included in Molecules in 2011.Recommanded Product: 18437-66-6 This article mentions the following:
Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), several quinolinone derivatives were designed and the synthesis of the target compounds [4-(phenylthio)-2(1H)-quinolinone derivatives, 4-(phenoxy)-2(1H)-quinolinone derivatives, 4-phenyl-2(1H)-quinolinone derivatives] was achieved using chloroquinolines as key intermediates. The title compounds were assayed for their in-vitro activity against HIV-1 reverse transcriptase (RT) for the first time and it was discovered that some of the tested compounds were active against HIV-1 RT [RNA-dependent deoxyribonucleate nucleotidyltransferase (human immunodeficiency virus 1)]. Two compounds displayed inhibitory activities with IC50 values of 0.21 and 0.15 μM, resp., with a mode of interaction with RT residues of the allosteric pocket similar to that of Efavirenz. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Recommanded Product: 18437-66-6).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 18437-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics