Hydrogen Chloride Gas in Solvent-Free Continuous Conversion of Alcohols to Chlorides in Microflow was written by Borukhova, Svetlana;Noel, Timothy;Hessel, Volker. And the article was included in Organic Process Research & Development in 2016.Application of 697-73-4 This article mentions the following:
Chlorides represent a class of valuable intermediates that are utilized in the preparation of bulk and fine chems. An earlier milestone to convert bulk alcs. to corresponding chlorides was reached when hydrochloric acid was used instead of toxic and wasteful chlorinating agents. This paper presents the development of an intensified solvent-free continuous process by using hydrogen chloride gas only. The handling of corrosive hydrogen chloride became effortless when the operating platform was split into dry and wet zones. The dry zone is used to deliver gas and prevent corrosion, while the wet zone is used to carry out the chem. transformation. The use of gas instead of hydrochloric acid allowed a decrease in hydrogen chloride equivalent from 3 to 1.2. In 20 min residence time, full conversion of benzyl alc. yielded 96 weight % of benzyl chloride in the product stream. According to green chem. and engineering principles, the developed process is of an exemplary type due to its truly continuous nature, no use of solvent and formation of water as a sole byproduct. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Application of 697-73-4).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 697-73-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics