Sustainable and chemoselective N-Boc protection of amines in biodegradable deep eutectic solvent was written by Azizi, Najmedin;Shirdel, Fatemeh. And the article was included in Monatshefte fuer Chemie in 2017.Name: tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:
A green and practical approach for the chemoselective N-tert-butyloxycarbonylation of structurally diverse amines with di-tert-Bu dicarbonate (Boc2O) is described. Selective N-Boc protection was achieved in excellent yields in urea-choline chloride deep eutectic solvent (DES) as the most promising environmentally benign and cost-effective solvent under mild reaction conditions. DES can protect various aromatic and aliphatic amines using Boc2O in good to excellent yields in short reaction times without any side products. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Name: tert-Butyl (4-chlorophenyl)carbamate).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: tert-Butyl (4-chlorophenyl)carbamate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics