Almstead, Neil G. et al. published their research in Journal of Medicinal Chemistry in 1999 | CAS: 1138-56-3

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 1138-56-3

Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors was written by Almstead, Neil G.;Bradley, Rimma S.;Pikul, Stanislaw;De, Biswanath;Natchus, Michael G.;Taiwo, Yetunde O.;Gu, Fei;Williams, Lisa E.;Hynd, Barbara A.;Janusz, Michael J.;Dunaway, C. Michelle;Mieling, Glen E.. And the article was included in Journal of Medicinal Chemistry in 1999.HPLC of Formula: 1138-56-3 This article mentions the following:

The synthesis and enzyme inhibition data for a series of thiazine- and thiazepine-based matrix metalloproteinase (MMP) inhibitors are described. The thiazine- and thiazepine-based inhibitors were discovered by optimization of hetererocyclic sulfonamide-based inhibitors. The most potent series of inhibitors was obtained by modification of the amino acid D-penicillamine. This amino acid provides a gem-di-Me group on the thiazine or thiazepine ring which has a dramatic effect on the in vitro potency of this series. In particular, the sulfide I [n = 0] and the sulfone I [n = 2] were potent, broad-spectrum inhibitors of the MMPs with IC50‘s against MMP-1 of 0.8 and 1.9 nM, resp. The binding mode of this novel thiazepine-based series of MMP inhibitors was established based on X-ray crystallog. of the complex of stromelysin and I [n = 0]. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3HPLC of Formula: 1138-56-3).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 1138-56-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics