Month: December 2022

Wang, Qiuzhu published the artcileSynthesis of β-Polychlorinated Alkynes Enabled by Copper-Catalyzed Multicomponent Reaction, Formula: C5H10Cl3O3P, the publication is Organic Letters (2022), 24(26), 4772-4777, database is CAplus and MEDLINE.

Functional mols. bearing polychlorinated moieties usually play versatile roles in organic synthesis and biochem. A copper-catalyzed multicomponent polychloro-carboalkynylation of alkenes presents an efficient and operationally simple approach for the synthesis of β-polychlorinated alkynes. Mechanistic experiments were conducted demonstrating that an in situ generated copper acetylide complex was the real catalyst and reactive intermediate during the copper-catalytic cycle. And enantioselective exploration demonstrated potential application for the synthesis of chiral β-polychlorinated alkynes.

Organic Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C13H11NO, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Yannian published the artcileRationally Designed Axially Chiral Diarylethene Switches with High Helical Twisting Power, Related Products of chlorides-buliding-blocks, the publication is Chemistry – A European Journal (2014), 20(49), 16286-16292, database is CAplus and MEDLINE.

Three rationally designed axially chiral diarylethene switches were synthesized and their application as chiral dopants for phototunable cholesteric liquid crystal devices was investigated. Design of these mols. was based on the combination of photochromic dithienylcyclopentene core with bridged binaphthyl units as chiral precursors. Aromatic groups were introduced to the mols. at 6,6′-positions of binaphthyls through a Suzuki-Miyaura coupling reaction. Their helical twisting powers (HTPs) are significantly higher than those of the known chiral diarylethenes reported as chiral dopants so far. Photocyclization of these mols. upon light irradiation brought out dramatic variation in HTPs between different states. The primary colors, red, green, and blue, were obtained in reflection on light irradiation and with thermal stability. Moreover, a multi-switchable photodisplay was demonstrated using one of these chiral mol. switches.

Chemistry – A European Journal published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ding, Siyi published the artcileNNB-type tridentate boryl ligands enabling a highly active iridium catalyst for C-H borylation, SDS of cas: 929626-16-4, the publication is Molecules (2019), 24(7), 1434, database is CAplus and MEDLINE.

Boryl ligands play a very important role in catalysis because of their very high electron-donating property. NNB-type boryl anions were designed as tridentate ligands to promote aryl C-H borylation. In combination with [IrCl(COD)]₂, they generate a highly active catalyst for a broad range of (hetero)arene substrates, including highly electron-rich and/or sterically hindered ones. This work provides a new NNB-type tridentate boryl ligand to support homogeneous organometallic catalysis.

Molecules published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO3, SDS of cas: 929626-16-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Huarong published the artcileA novel and green method for the synthesis of 4-thiazolidinones with 2-chloroacetamide and thioureas, HPLC of Formula: 3696-23-9, the publication is Youji Huaxue (2014), 34(4), 761-766, database is CAplus.

A novel, green synthetic method for 4-thiazolidinones in the ionic liquids was reported. 4-Thiazolidinones were prepared with the substituted thioureas and 2-chloroacetamide in the ionic liquids This method offers several advantages such as high yield, short reaction time and mild reaction conditions. The reaction mechanism was studied and the result showed that ammonia was removed in the reaction, which was the first reported.

Youji Huaxue published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C3H6O2, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhan, Bei-Bei published the artcileSynthesis of Axially Chiral Biaryl-2-amines by Pd^II-Catalyzed Free-Amine-Directed Atroposelective C-H Olefination, Computed Properties of 209919-30-2, the publication is Angewandte Chemie, International Edition (2020), 59(9), 3568-3572, database is CAplus and MEDLINE.

A simple and ubiquitously present group, free amine, is used as a directing group to synthesize axially chiral biaryl compounds by Pd^II-catalyzed atroposelective C-H olefination. A broad range of axially chiral biaryl-2-amines can be obtained in good yields with high enantioselectivities (up to 97% ee). Chiral spiro phosphoric acid (SPA) proved to be an efficient ligand and the loading could be reduced to 1 mol % without erosion of enantiocontrol in gram-scale synthesis. The resulting axially chiral biaryl-2-amines also provide a platform for the synthesis of a set of chiral ligands.

Angewandte Chemie, International Edition published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C24H29N5O3, Computed Properties of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Shichao published the artcileVisible-Light Photoredox-Catalyzed Regioselective Sulfonylation of Alkenes Assisted by Oximes via [1,5]-H Migration, Computed Properties of 32333-53-2, the publication is Journal of Organic Chemistry (2020), 85(2), 564-573, database is CAplus and MEDLINE.

Herein, a visible-light photoredox-catalyzed regioselective sulfonylation of alkenes with sulfonyl hydrazides assisted by oximes at room temperature, which affords a variety of sulfones in good yields is reported. The initial mechanistic experiments demonstrate that the hydroxyl group within oximes plays a crucial role in this sulfonylation.

Journal of Organic Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C5H10O, Computed Properties of 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Sheng published the artcileNi-Catalyzed Reductive Arylacylation of Alkenes toward Carbonyl-Containing Oxindoles, Computed Properties of 939-99-1, the publication is Organic Letters (2019), 21(18), 7498-7503, database is CAplus and MEDLINE.

Using iso-Bu chloroformate as a carbon monoxide equivalent, N-(bromoaryl) α-substituted acrylamides such as I underwent reductive arylacylation reactions with alkyl iodides such as iodocyclohexane or benzylic chlorides in the presence of NiBr₂(DME), and 4,4′-dimethyl-2,2′-bipyridine using manganese or zinc as reductant in 1:1 DMA:THF to yield oxoalkyl oxindoles such as II. The mechanism was studied using an alkyl iodide susceptible to radical cyclization and stoichiometric reaction of a oxindolylmethyl nickel complex; a mechanism involving reaction of alkyl radicals with nickel complexes is proposed. Reaction using a nonracemic octahydrobinaphthyl phosphoramidate ligand yielded product in 8% yield and 50% ee.

Organic Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C22H32O2, Computed Properties of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bao, Ting published the artcileSynthesis and structure of lateral halogenated V-shaped liquid crystal molecules based on a 1,7-naphthalene central core and alkylthio tails, Synthetic Route of 350-30-1, the publication is Liquid Crystals (2014), 41(12), 1687-1695, database is CAplus.

A series of small angle bent-core (V-shaped) mesogens carrying 1,7-naphthalene as a central core linked with lateral halogenated (chlorinated or fluorinated) Schiff-base side wings and alkylthio terminal tails of variable carbon number (n = 12, 16) was synthesized in order to reduce the transition temperature and improve the phase stability of bent-core liquid crystal mols. Differential scanning calorimetry (DSC), polarising optical microscopy (POM), small-angle X-ray scattering system (SAXS) and two-dimensional X-ray diffractometer were applied to ascertain the mesomorphic structure and phase transition temperatures of the compounds The results confirm that all the mols. show thermotropic liquid crystalline behavior and exhibit hexagonal columnar phase (Colh) in a certain temperature range. Compared with the homologous compounds without lateral halogen, the cleaning point temperature of lateral halogenated V-shaped compounds generally decrease and the Colh phase ranges are more extensive. The influence of lateral chlorine on the cleaning point temperature is more obvious, as well as the effect of lateral fluorine on the range of Colh phase.

Liquid Crystals published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Synthetic Route of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Lian-Fang published the artcileSyntheses of methadone and 5-nitrofurfural, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Bulletin of the Institute of Chemistry, Academia Sinica (1980), 13-17, database is CAplus.

EtCOCPh₂CH₂CHMeNMe₂ (I), was prepared from ClCH₂CHMeOH (II) in 4 steps. Thus, amination of II with Me₂NH and subsequent SOCl₂ chlorination gave Me₂NCH₂CHClMe, which condensed with Ph₂CHCN in aqueous NaOH to give Ph₂C(CN)CH₂CHMeNMe₂. Reaction of the latter with EtMgBr and subsequent hydrolysis gave I. Nitration of furfural by HNO₃-H₂SO₄ in Ac₂O gave 2-(diacetoxymethyl)-5-nitrofuran, which was treated with 73% H₂SO₄ to give 5-nitrofurfural, an intermediate in the preparation of furazolidone.

Bulletin of the Institute of Chemistry, Academia Sinica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gao, Sai-nan published the artcileExperimental study on activated carbon adsorption for treating effluents from oil-field wastewater treatment facilities, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane, the publication is Huanjing Kexue Yu Jishu (2010), 33(12), 56-61, 65, database is CAplus.

An on-site pilot experiment was conducted, which involved application of granular activated carbon (GAC) adsorption to advanced treatment of the effluent from an oil-field wastewater treatment facility equipped with separation-coagulation-filtration plus biol. hydrolytic acidification-oxidation process. The experiment included both static adsorption using a shaker and dynamic adsorption operated in a plexiglass column. Based on the continuous run, this paper put forward the adsorption design data for engineering application. Besides, GC-MS was used to verify the removals by adsorption of halo-hydrocarbons, heterocyclic compounds and carboxylic acid derivatives It was also found that major compounds in the treated effluent were large mol. organic acids, which were identified as non-polar hydrophobic organic compounds through the anal. of organic conceptual diagram.

Huanjing Kexue Yu Jishu published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics