Month: December 2022

Chen, Yiding published the artcileCopper(I)-catalyzed sulfonylative Suzuki-Miyaura cross-coupling, Name: (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid, the publication is Chemical Science (2017), 8(4), 3249-3253, database is CAplus and MEDLINE.

By using a simple copper(I) catalyst a high yielding sulfonylative-Suzuki-Miyaura cross-coupling reaction was developed. The process provided a single step route to diaryl sulfones from the direct combination of arylboronic acids, sulfur dioxide and aryl iodides, and represents the first sulfonylative variant of a classic cross-coupling reaction. Sulfur dioxide was delivered from the surrogate reagent, DABSO. Variation of the reaction conditions allowed interruption of the sulfonylative-Suzuki coupling, resulted in the formation of a presumed Cu-sulfinate intermediate. These sulfinates was trapped as their sodium salts and treated with electrophiles to allow access to arylalkyl sulfones, β-hydroxyl sulfones, sulfonamides and sulfonyl fluorides.

Chemical Science published new progress about 870778-91-9. 870778-91-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid, and the molecular formula is C13H12BClO3, Name: (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Apgar, James M. published the artcileMK-5204: An orally active β-1,3-glucan synthesis inhibitor, Synthetic Route of 7080-50-4, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(17), 127357, database is CAplus and MEDLINE.

Our previously reported efforts to produce an orally active β-1,3-glucan synthesis inhibitor through the semi-synthetic modification of enfumafungin focused on replacing the C2 acetoxy moiety with an aminotetrazole and the C3 glycoside with a N,N-dimethylaminoether moiety. This work details further optimization of the C2 heterocyclic substituent, which identified 3-carboxamide-1,2,4-triazole as a replacement for the aminotetrazole with comparable antifungal activity. Alkylation of either the carboxamidetriazole at C2 or the aminoether at C3 failed to significantly improve oral efficacy. However, replacement of the iso-Pr α-amino substituent with a t-Bu, improved oral exposure while maintaining antifungal activity. These two structural modifications produced MK-5204, which demonstrated broad spectrum activity against Candida species and robust oral efficacy in a murine model of disseminated Candidiasis without the N-dealkylation liability observed for the previous lead.

Bioorganic & Medicinal Chemistry Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Synthetic Route of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Apgar, James M. published the artcileIbrexafungerp: An orally active β-1,3-glucan synthesis inhibitor, SDS of cas: 5034-06-0, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127661, database is CAplus and MEDLINE.

We previously reported medicinal chem. efforts that identified MK-5204 (I), an orally efficacious β-1,3-glucan synthesis inhibitor derived from the natural product enfumafungin. Further extensive optimization of the C2 triazole substituent identified 4-pyridyl as the preferred replacement for the carboxamide of MK-5204, leading to improvements in antifungal activity in the presence of serum, and increased oral exposure. Reoptimizing the aminoether at C3 in the presence of this newly discovered C2 substituent, confirmed that the (R) t-Bu, Me aminoether of MK-5204 provided the best balance of these two key parameters, culminating in the discovery of ibrexafungerp (II), which is currently in phase III clin. trials. Ibrexafungerp displayed significantly improved oral efficacy in murine infection models, making it a superior candidate for clin. development as an oral treatment for Candida and Aspergillus infections.

Bioorganic & Medicinal Chemistry Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, SDS of cas: 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wrobel, Zbigniew published the artcileThe reported formation of 5H-dibenzo [b,e][1,4]diazepin-11( 10H )-ones in the noncatalyzed, base-promoted double arylation of anthranilamide revisited. Correction of some product structures, Category: chlorides-buliding-blocks, the publication is Journal of Heterocyclic Chemistry (2021), 58(9), 1802-1808, database is CAplus.

The base-promoted reaction of 2-halonitro- or 1,2-dihalobenzenes with anthranilamide reported by Cao, Ma et al. (Synthesis2013, 45, 111) was reinvestigated. Some of the products reported, which was identified as dibenzodiazepinones, were actually benzoxazole derivatives In this paper, the correct structures of these products were established and confirmed by independent synthesis. For four other products, the supposed structures were found to be incompatible with the dibenzodiazepinones that were synthesized by the reliable method used.

Journal of Heterocyclic Chemistry published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C6H17NO3Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lochmueller, C. H. published the artcileQuantitative photoacoustic spectroscopy of chemically-modified silica surfaces, Recommanded Product: Dichloro(hexyl)(methyl)silane, the publication is Analytica Chimica Acta (1980), 118(1), 101-8, database is CAplus.

The degree of surface coverage on chem.-modified silica gel was determined by using photoacoustic spectroscopy. Vibrational overtones in the near IR were employed for the examination of modified materials containing bonded aliphatic, aromatic, and aminoalkyl functions. A linear relation between photoacoustic signal amplitude and C or N content of the chem.-modified surface was obtained.

Analytica Chimica Acta published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Recommanded Product: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lochmueller, C. H. published the artcileQuantitative photoacoustic spectroscopy of chemically-modified silica surfaces, Formula: C9H20Cl2Si, the publication is Analytica Chimica Acta (1980), 118(1), 101-8, database is CAplus.

The degree of surface coverage on chem.-modified silica gel was determined by using photoacoustic spectroscopy. Vibrational overtones in the near IR were employed for the examination of modified materials containing bonded aliphatic, aromatic, and aminoalkyl functions. A linear relation between photoacoustic signal amplitude and C or N content of the chem.-modified surface was obtained.

Analytica Chimica Acta published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sorribes, Ivan published the artcileChemoselective Transfer Hydrogenation to Nitroarenes Mediated by Cubane-Type Mo₃S₄ Cluster Catalysts, SDS of cas: 350-30-1, the publication is Angewandte Chemie, International Edition (2012), 51(31), 7794-7798, S7794/1-S7794/4, database is CAplus and MEDLINE.

Cubane-type Mo₃S₄ cluster compounds catalyzed transfer hydrogenation to nitro arenes or nitro heteroarenes to give aromatic amines. E.g., in presence of formic acid and NEt₃ as the reducing agent, [Mo₃S₄H₃(dmpe)₂]BPh₄ catalyzed the transfer hydrogenation of 4-O₂NC₆H₄NH₂ to give 90% p-phenylenediamine.

Angewandte Chemie, International Edition published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C7H6Cl2O, SDS of cas: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Li published the artcileDirect Radiofluorination of Arene C-H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant, Category: chlorides-buliding-blocks, the publication is Organic Letters (2020), 22(20), 7971-7975, database is CAplus and MEDLINE.

Herein, we describe an organic photoredox system for direct arene C-H radiofluorination, using a peroxide oxidizing agent and LEDs as the light source. In conjunction with an optimized photocatalyst and a microtubing reactor, this system is applicable to a range of electron-rich aromatics and heteroaromatics We also demonstrate the feasibility of C-H radiofluorination without an azeotropic drying step, which greatly simplifies the workflow of the labeling process.

Organic Letters published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C20H17FO4S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Kuang-Yen published the artcileTetrapodal Molecular Switches and Motors: Synthesis and Photochemistry, Application In Synthesis of 219537-97-0, the publication is Journal of Organic Chemistry (2014), 79(15), 7032-7040, database is CAplus and MEDLINE.

The design, synthesis, and dynamic behavior of a series of novel tetrapodal mol. switches and motors containing common functional groups for attachment to various inorganic and organic surfaces are presented. Using a Diels-Alder reaction, an anthracene unit with four functionalized alkyl substituents (“legs”) was coupled to maleimide-functionalized mol. switches or motors under ambient conditions. Terminal functional groups at the “legs” include thioacetates and azides, making these switches and motors ideal candidates for attachment to metallic or alkyne-functionalized surfaces. UV/vis absorption spectroscopy shows that the mol. switches and motors retain their ability to undergo reversible photoinduced and/or thermally induced structural changes after attachment to the tetrapodal anthracene.

Journal of Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Griffiths, V. S. published the artcileDipole-moment measurements of coumarin derivatives and their orientation at a dropping-mercury electrode, SDS of cas: 10543-42-7, the publication is Journal of the Chemical Society (1963), 4941-5, database is CAplus.

The dipole moments of coumarin and its 6-amino-, 6-acetamido-, 6-sulfamoyl-, and 6-chlorosulfonyl derivatives were determined Coumarin derivatives are adsorbed with the dipole moment parallel to the Hg surface.

Journal of the Chemical Society published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, SDS of cas: 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics