Month: December 2022

Liu, Jian-Li published the artcilePalladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1H)-ones, COA of Formula: C8H6ClF3, the publication is Organic & Biomolecular Chemistry (2021), 19(16), 3584-3588, database is CAplus and MEDLINE.

An efficient carbonylative procedure for the synthesis of 3-arylquinoin-2(1H)-ones I (R¹ = H, 4-Me, 4-F, etc.) and II (R² = 6-OMe, 6-F, 6-Cl, etc.; R³ = H) has been established. Through a palladium-catalyzed aminocarbonylation of benzyl chlorides with anthranils, a variety of 3-arylquinoin-2(1H)-one products were obtained in moderate to excellent yields with good functional group tolerance.

Organic & Biomolecular Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, COA of Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileCharge-Transfer Complex Promoted Regiospecific C-N Bond Cleavage of Vicinal Tertiary Diamines, Recommanded Product: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Advanced Synthesis & Catalysis (2018), 360(18), 3502-3506, database is CAplus.

A catalyst-free, charge-transfer complex promoted coupling of sulfonyl chlorides RSO₂Cl (R = cyclopropyl, Ph, 3,5-F₂C₆H₃, 2-naphthyl, 2-thienyl, 8-quinolinyl, etc.) with vicinal tertiary diamines R¹R²NCH₂CH₂NR¹R² (R¹ = R² = Me, Et, n-Pr, i-Pr, i-Bu; R¹ = Me, R² = Ph, 3-MeC₆H₄, etc.; R¹R²N = 1-pyrrolidinyl, 4-morpholinyl) to generate sulfonamides RSO₂NR¹R² is presented. Mechanistic studies showed that these reactions proceed via charge transfer of vicinal tertiary diamines to sulfonyl chlorides, forming the unstable sulfonyl quaternary ammonium-like complexes which induce the regiospecific intramol. C-N bond cleavage of vicinal tertiary diamines.

Advanced Synthesis & Catalysis published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Recommanded Product: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Ying published the artcileSulfonylation of 1,4-Diazabicyclo[2.2.2]octane by Charge-Transfer Complex Triggered C-N Bond Cleavage, Quality Control of 21286-54-4, the publication is ChemistryOpen (2019), 8(1), 127-131, database is CAplus and MEDLINE.

A novel charge-transfer complex triggered sulfonylation of 1,4-diazabicyclo[2.2.2]octane (DABCO) with mild reaction conditions has been developed. The formation of a charge-transfer complex between electron-withdrawing (hetero)aryl sulfonyl chloride and DABCO allows the synthesis of N-ethylated piperazine sulfonamide in good yields. The reaction has a high functional group tolerance. Spectroscopic studies confirmed the charge-transfer complex formation between sulfonyl chlorides and DABCO, which facilitates the C-N bond cleavage of DABCO.

ChemistryOpen published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liang, Yong-min published the artcileFe₂(SO₄)₃·4H₂O/concentrated H₂SO₄. An efficient catalyst for esterification, Application In Synthesis of 866-23-9, the publication is Journal of Chemical Research (2004), 226-227, database is CAplus.

The mixed catalyst system, Fe₂(SO₄)₃·4H₂O/concentrated H₂SO₄ was applied to catalyze effectively the esterification of α,β-unsaturated acids, aliphatic acids and heterocyclic aromatic acids with ethanol and methanol.

Journal of Chemical Research published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

He, Weixuan published the artcileα-Elimination of diethyl dichlorolithiomethanephosphonate, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Huaxue Xuebao (1987), 45(3), 291-4, database is CAplus.

The α-elimination of (EtO)₂P(O)C^–Cl₂ Li⁺ generates dichlorocarbene, in which the leaving group is diethyl phosphite anion not Cl^–. A discussion on the reaction is given.

Huaxue Xuebao published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Guanghui published the artcileDouble N,B-Type Bidentate Boryl Ligands Enabling a Highly Active Iridium Catalyst for C-H Borylation, Computed Properties of 929626-16-4, the publication is Journal of the American Chemical Society (2015), 137(25), 8058-8061, database is CAplus and MEDLINE.

Boryl ligands hold promise in catalysis due to their very high electron-donating property. In this communication double N,B-type boryl anions were designed as bidentate ligands to promote an sp² C-H borylation reaction. A sym. pyridine-containing tetraaminodiborane(4) compound was readily prepared as the ligand precursor that could be used, in combination with [Ir(OMe)(COD)]₂, to in situ generate a highly active catalyst for a broad range of (hetero)arene substrates including highly electron-rich and/or sterically hindered ones. This work provides the 1st example of a bidentate boryl ligand in supporting homogeneous organometallic catalysis.

Journal of the American Chemical Society published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C14H21BO2, Computed Properties of 929626-16-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Maiti, Rakesh published the artcileCarbene-catalyzed selective addition of isothioureas to enals for access to sulphur-containing 5,6-dihydropyrimidin-4-ones, HPLC of Formula: 3696-23-9, the publication is Organic Chemistry Frontiers (2021), 8(4), 743-747, database is CAplus.

A carbene-catalyzed addition reaction between isothioureas and enals under oxidative conditions was reported. The key steps of these reactions was the formation of two carbon-nitrogen bonds in a highly regioselective manner. A variety of sulfur-containing 5,6-dihydropyrimidin-4-ones were obtained with high optical purity.

Organic Chemistry Frontiers published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Mingjuan published the artcileCopper immobilized on biomimetic assembled calcium carbonate/carboxymethylcellulose hybrid: a highly active recoverable catalyst for CuAAC reactions, Formula: C7H6Cl2, the publication is Research on Chemical Intermediates (2021), 47(9), 3883-3898, database is CAplus.

A novel copper immobilized on biomimetic assembled CM-cellulose/calcium carbonate hybrid (Cu^II@CMC/CaCO₃) as an efficient heterogeneous catalyst for the synthesis of 1,2,3-triazoles has been described herein. The fabrication of Cu^II@CMC/CaCO₃ is accomplished through a bioinspired mineralization process using sodium CM-cellulose (CMC-Na) as the template and ion exchange agent, while the metathesis, nucleation, assemble, hybridization, and immobilization of Cu(II) occurred by successful treatment with CaCl₂, Na₂CO₃, and CuSO₄ in water at room temperature The resultant Cu^II@CMC/CaCO₃ hybrid was well characterized by various analyses such as FT-IR, XRD, SEM, EDX, EDX-mapping, TEM, and TGA techniques. In the presence of low copper loading of Cu^II@CMC/CaCO₃ hybrid, benzylic halides, azide, and alkynes proceeded smoothly to afford 1,4-disubstituted 1,2,3-triazoles in high yields. The catalyst can be conveniently recovered from the reaction mixture by filter and reused for at least 5 consecutive runs with a slight drop in its catalytic activity. The remarkable activity and stability of the catalyst may be attributed to the coordination of both carboxyl and hydroxyl groups of the hybrid of CMC/CaCO₃.

Research on Chemical Intermediates published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C9H7NO4, Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Zhian published the artcileCuSO₄ nanoparticles loaded on carboxymethylcelulose/polyaniline composites: A highly efficient catalyst with enhanced catalytic activity in the synthesis of propargylamines, benzofurans, and 1,2,3-triazoles, Recommanded Product: 3-Chlorobenzylchloride, the publication is Applied Organometallic Chemistry (2021), 35(10), e6349, database is CAplus.

A novel and efficient heterogeneous CuSO₄ nanoparticles (CuSO₄ NPs) immobilized on CM-cellulose/polyaniline (CuSO₄NPs@CMC/PANI) composites were prepared via one-pot and one-step interfacial oxidative polymerization of aniline with sodium CM-cellulose (CMC) as soft template and CuSO₄ as catalyst. The in situ formed CuSO₄ NPs were dispersed uniformly and firmly on the resultant composites and stabilized by complexation with hydroxyl groups (OH), carboxylate groups (COO^–), nitrogen atoms, and delocalized π-π conjugate benzenoid and quinoid moieties of CMC/PANI composites. The morphol., composition, and structure of the as-fabricated composites were systematically characterized by XPS, transmission electron microscopy (TEM), SEM (SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier transform IR spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric anal. (TGA), and derivative thermogravimetry (DTG) techniques. The CuSO₄NPs@CMC/PANI composites were successfully applied as catalysts in aldehyde-alkyne-amine (A³) coupling reactions, A³-cycloisomerization tandem reactions, and Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. All reactions proceeded smoothly and afforded the desired products in excellent yields. Moreover, no significant decrease in catalytic ability was observed in A³ model reaction after 15 recycles, indicating CuSO₄NPs@CMC/PANI composites exhibited easy separability and high reusability. Tolerance of wide scope of substrate, excellent catalytic activity, easy operation, recycling of catalyst, and environmental benign are the salient features of these catalytic process.

Applied Organometallic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C13H10O3, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Daohai published the artcileStructure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of Medicinal Chemistry (2021), 64(12), 8194-8207, database is CAplus and MEDLINE.

The cocrystal structure of EZH2-embryonic ectoderm development (EED) in complex with astemizole at 2.15 Å was reported. The structure elucidated the detailed binding mode of astemizole to EED and provided a structure-guided design for the discovery of a novel EZH2-EED interaction inhibitor, DC-PRC2in-01 I, with an affinity Kd of 4.56μM. DC-PRC2in-01 I destabilized the PRC2 complex, thereby leading to the degradation of PRC2 core proteins and the decrease of global H3K27me3 levels in cancer cells. The proliferation of PRC2-driven lymphomas cells was effectively inhibited, and the cell cycle was arrested in the G0/G1 phase. Together, these data demonstrated that DC-PRC2in-01 I could be an effective chem. probe for investigating the PRC2-related physiol. and pathol. and providing a promising chem. scaffold for further development.

Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics